APOL1 is a gene that provides instructions for making a protein found in cells throughout the body, including those in the kidneys. Variations (mutations) in this gene, known as APOL1 risk alleles, have been linked to an increased risk of developing certain types of kidney disease, particularly in individuals of African descent.
Here’s a simplified explanation:
- Gene: A gene is a unit of heredity that carries instructions for making a specific protein.
- Mutation: A mutation is a permanent change in the DNA sequence of a gene.
- APOL1 risk alleles: These are specific variations in the APOL1 gene that increase the risk of developing kidney disease.
Indeed, the APOL1 program is focused on researching the impact of these genetic variants and developing targeted treatments for individuals with APOL1-related kidney disease. We are committed to advancing knowledge and improving outcomes for individuals with this genetic risk factor.
Be a part of our APOL1 research trial and help us in our quest to understand and treat this genetic condition. Register your interest here.